Aloe Vera

324 ALOE
MEDLINE EXPRESS (R) 1984-1990 1 of 324
TI: [Protective effect of extracts from Aloe vera L. var. chinensis (Haw.) Berg. on experimental hepatic lesions and a primary clinical study on the injection of in patients with hepatitis]
AU: Fan-YJ; Li-M; Yang-WL; Qin-L; Zou-J
SO: Chung-Kuo-Chung-Yao-Tsa-Chih. 1989 Dec; 14(12): 746-8
ISSN: 1001-5302
LA: CHINESE; NON-ENGLISH
AB: The injection(10-15 ml/kg/d, ip x 4), total glycoside (125-225 mg/kg/d, ip x (3-4); 600 mg/kg/d, ig x 3) and crystal III (120 mg/kg/d, ip x 4) of Aloe vera var. chinensis were found to be effective in lowering the elevated sGPT induced by CCl4, thioacetamide and D-aminogalactose in mice or rats. It was also observed that these agents could protect hepatic cells from the CCl4-induced injury. When dogs were given in with Aloe injection of 0.1 ml/kg/d x 180, no toxicity was noted. The total effective sGPT-lowering rate of Aloe injection on 38 patients of chronic hepatitis with positive HBsAg was 86.8%.
AN: 90248098
MEDLINE EXPRESS (R) 1984-1990 2 of 324
TI: The role of topical agents in the healing of full-thickness wounds.
AU: Watcher-MA; Wheeland-RG
AD: Department of Dermatology, University of California, Sacramento 95816.

SO: J-Dermatol-Surg-Oncol. 1989 Nov; 15(11): 1188-95

This title is owned by this library

ISSN: 0148-0812

LA: ENGLISH

AB: Eight topical agents in current use were studied for their effects on wound contraction and rate of reepithelialization of full-thickness excisions using a porcine animal model. The following agents were applied daily for a period of 27 days: scarlet red ointment, benzoyl peroxide lotion, bacitracin ointment, silver sulfadiazine cream, aloe vera gel, tretinoin cream, capsaicin cream, and mupirocin ointment. The rate of reepithelialization was significantly enhanced by treatment with capsaicin, bacitracin, silver sulfadiazine, and scarlet red, and was markedly retarded by treatment with tretinoin. Wound contraction was significantly retarded by mupirocin, bacitracin, and silver sulfadizine. Knowledge of the effects of topical agents on various aspects of healing allows the clinician to choose the most appropriate material to use in a given clinical situation to optimize the healing process and produce the best final result.

AN: 90037909

MEDLINE EXPRESS (R) 1984-1990 3 of 324

TI: Adrenalectomy decreases nerve growth factor in young adult rat hippocampus.

AU: Aloe-L

AD: Istituto di Neurobiologia, Consiglio Nazionale della Ricerca, Rome, Italy.

SO: Proc-Natl-Acad-Sci-U-S-A. 1989 Jul; 86(14): 5636-40

This title is owned by this library

ISSN: 0027-8424

LA: ENGLISH

AB: The effect of adrenalectomy on the level of nerve growth factor (NGF) in the hippocampus and on the distribution of choline acetyltransferase immunoreactivity in forebrain cholinergic neurons of developing rats was studied. Biological and immunohistochemical determinations indicated that in 40-day-old rats, adrenalectomy reduced the NGF level in the hippocampus and the choline acetyltransferase immunoreactivity in the septal lateral bands. Furthermore, autoradiographic studies showed that adrenalectomy causes changes in the distribution and expression of NGF receptors in the hippocampus. These results suggest that adrenal hormones are involved in the regulation of the NGF level in the hippocampus and of NGF receptors in the septum.

AN: 89315852

MEDLINE EXPRESS (R) 1984-1990 4 of 324

TI: Effect of water extracts of aloe and some herbs in decreasing blood ethanol concentration in rats. II.

AU: Sakai-K; Saitoh-Y; Ikawa-C; Nishihata-T

SO: Chem-Pharm-Bull-Tokyo. 1989 Jan; 37(1): 155-9

This title is owned by this library

ISSN: 0009-2363

LA: ENGLISH

AB: Oral administration of ethanol to rats at a dose of 3 g/kg decreased alcohol dehydrogenase (ADH) activity and metabolism of lactate to pyruvate in the liver. The effects of water extracts of Aloe and some other herbs on blood ethanol concentration and on ADH activity in liver cytosol were examined. The water extracts of these herbs caused a faster elimination of ethanol from blood of normal rats when administered orally 30 min before oral administration of ethanol. The rapid elimination of ethanol seems to be due to a protection of ADH activity and the supply of nicotinamide dinucleotide, both of which are reduced by high ethanol concentration. The effects of ethanol in decreasing the enzyme activities relating to its own metabolism occur when high concentrations of ethanol pass through the liver, and thus may primarily appear during the absorption of alcohol from the gastrointestinal tract, when portal concentration of ethanol are very high.

AN: 89249527

MEDLINE EXPRESS (R) 1984-1990 5 of 324

TI: [Evaluation of the cationic-lysosomal test in patients with pneumonia against a background of therapy]

TO: Otsenka kationno-lizosomal'nogo testa u bol'nykh pnevmoniei na fone terapii.

AU: Domashenko-ON; Sotnik-IuP

SO: Lab-Delo. 1989(5): 15-7

This title is owned by this library

ISSN: 0023-6748

LA: RUSSIAN; NON-ENGLISH

AB: The authors' findings evidence that measurements of cationic protein levels is a sufficiently informative test in the complex of investigations that help predict the course of acute pneumonia and the therapeutic efficacy of drugs stimulating the nonspecific resistance of the body. Combined therapy with the use of methyluracil and eleutherococcus is more effective for pneumonia patients than the complex including aloe and antibacterial and symptomatic agents alone.

AN: 89312532

MEDLINE EXPRESS (R) 1984-1990 6 of 324

TI: [A comprehensive assessment of the phagocytic activity of the blood neutrophils in patients with rubromycosis treated with griseofulvin and nizoral]

TO: Kompleksnaia otsenka fagotsitarnoi aktivnosti neitrofilov krovi u bol'nykh rubrofitiei, lechennykh grizeoful'vinom i nizoralom.

AU: Belukha-UK; Bidrat-MS; Luk'ianova-AS

SO: Vestn-Dermatol-Venerol. 1989(1): 50-2

ISSN: 0042-4609

LA: RUSSIAN; NON-ENGLISH

AB: The neutrophilic phagocytic activity (absorption and enzymic bactericidal) is intensified in rubromycosis patients treated with nizoral vs. those administered griseofulvin. it is advisable to combine griseofulvin therapy with biogenic stimulants (pyrogenal, aloe, fiBS, vitreous body).

AN: 89243798

MEDLINE EXPRESS (R) 1984-1990 7 of 324

TI: [Acute myeloid leukemia: prognostic factors]

TO: Leucemia mieloide acuta: fattori prognostici.

AU: Petti-MC; Aloe-Spiriti-MA; Latagliata-R; Spadea-A; Tirindelli-MC; Vegna-ML

SO: Haematologica. 1989 Oct; 74(5 Suppl): 380-91

This title is owned by this library

ISSN: 0390-6078

LA: ITALIAN; NON-ENGLISH

AN: 90077150

MEDLINE EXPRESS (R) 1984-1990 8 of 324

TI: Adult acute lymphoblastic leukemia: description and analysis of long-term survivors. A retrospective study.

AU: Giona-F; Mazzucconi-MG; Aloe-Spiriti-MA; Defazio-D; De-Luca-AM; Ferrazza-G; Martinelli-E; Mandelli-F

SO: Haematologica. 1989 Sep-Oct; 74(5): 475-80

This title is owned by this library

ISSN: 0390-6078

LA: ENGLISH

AB: This retrospective study, including 118 patients with acute lymphoblastic leukemia (ALL) aged greater than 15 years, with a minimum follow-up of 6 years, was aimed at defining potentially "cured" adults with ALL. At present, 21 out of 92 patients who achieved complete remission (CR) are long survivors: 16 in first CR, off-therapy; 4 in 2nd CR (3 off-therapy); 1 in 3rd CR, on treatment. On the basis of available data, we tried to identify factors at diagnosis which might predict long-term survival: white blood cell (WBC) count on admission was the only significant prognostic factor for overall survival (p = 0.0002) and first CR duration (p = 0.0005). The survival hazard rate (risk of death from acute leukemia per day) reaches 0 between 8 and 9 years from diagnosis. From our data we can identify two groups of ALL long-term survivors: the first includes 16 patients in 1st continuous CR (CCR), 12 of whom in CCR for over 8 years may be considered "cured"; the second group comprises 5 patients, relapsing once or twice, alive in 2nd or 3rd CR.

AN: 90060996

MEDLINE EXPRESS (R) 1984-1990 9 of 324

TI: Intensification in post-remission treatment of adult acute non lymphocytic leukemia.

AU: Petti-MC; Aloe-Spiriti-MA; Carella-AM; Fioritoni-G; Resegotti-L; Rizzoli-V; Tabilio-A; Visani-G; Vegna-ML; Mandelli-F

SO: Haematologica. 1989 May-Jun; 74(3): 267-71

This title is owned by this library

ISSN: 0390-6078

LA: ENGLISH

AB: In an attempt to reduce the risk of leukemic relapse, different post-remission intensifications based on high-dose Ara-C (HiDAC) and autologous bone marrow transplantation (ABMT) were evaluated in patients with acute non lymphocytic leukemia in first remission and compared as to response and toxicity. Between September, 1985 and May, 1987, 34 patients in complete remission were eligible for our study. Induction therapy consisted of one or two courses of daunorubicin (DNR) and Ara-C (schedule 3 + 7). Fourteen patients receiving intensive post-remission chemotherapy with DNR + Ara-C (schedule 2 + 5), HiDAC + DNR, and ABMT following pretransplant BAVC conditioning entered the first pilot study. A high toxicity was observed and only 5 of them completed the full treatment plan. Thus the second pilot study used a single post-remission intensive course with HiDAC + m-AMSA and ABMT following cyclophosphamide plus TBI or BAVC. This approach was more feasible. The preliminary results show the usefulness of intensive post-remission therapy: in fact, all patients but one who completed the treatment program are still in continuous complete remission. A large number of patients and a longer follow-up are required to draw final conclusions.

AN: 90060972

MEDLINE EXPRESS (R) 1984-1990 10 of 324

TI: Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet.

AU: Sakai-R

AD: Department of Epidemiology, School of Health Sciences, Ryukyu University, Okinawa.

SO: Jpn-J-Cancer-Res. 1989 Jun; 80(6): 513-20

This title is owned by this library

ISSN: 0910-5050

LA: ENGLISH

AB: This case-control study of lung cancer was based on a cross-sectional questionnaire survey of inpatients at 5 general hospitals in Okinawa, Japan, from 1982 to 1987. The purpose of the study was to clarify the relations of lung cancer to cigarette smoking and plant diet. Ingestion frequencies of 17 major dietary plants and/or herbs were obtained by means of a questionnaire interview. As eligible subjects for a case-control analysis, there were 673 respondents aged over 30 years with clear smoking history, age, sex and diagnosis. Psychiatric patients were excluded. Odds ratios of newly diagnosed lung cancer were calculated by the Mantel-Haenszel procedure. A pair consisted of a case and two controls which were selected randomly by using multivariate caliper matching. Sixty-four pairs matched for age (+/- 5) and sex showed a significantly high odds ratio of 2.9 (P less than 0.0005). However, three male groups who were categorized by the number of cigarettes smoked did not exhibit dose-dependency of lung cancer on smoking. Lung cancer was more prevalent in ex-smokers than in current smokers. Case-control analyses by male generations revealed that lung cancer incidence was age-dependent, and there was a clear dose-response relationship between smoking and lung cancer in males in their sixties. A case-control analysis of each of 17 edible plants based on 44 pairs who were matched for age (+/- 5), sex and smoking history demonstrated that the odds ratio of aloe (Aloe arborescens Mill var. natalensis Berger) was 0.5 (P less than 0.1), suggesting that the aloe may prevent human carcinogenesis at various sites.

AN: 89340133

MEDLINE EXPRESS (R) 1984-1990 11 of 324

TI: [Prospective study of the immunomodulator properties of i.m. administered "ALVA" extract in patients with solid tumors under a course of chemical immunosuppressive therapy]

TO: Etude prospective des proprietes immunomodulatrices de l'extrait "ALVA" utilise en "I.M." chez des patients atteints de tumeurs solides et en cours de therapie immunosuppressive chimique.

AU: Michel-P; Pignon-T; Ralamboranto-L; Randrianandraina-S; Ratovonarivo-A; Coulanges-P

AD: Institut Pasteur Antannerivo.

SO: Arch-Inst-Pasteur-Madagascar. 1989; 56(1): 253-9

This title is owned by this library

ISSN: 0020-2495

LA: FRENCH; NON-ENGLISH

AN: 90225894

MEDLINE EXPRESS (R) 1984-1990 12 of 324

TI: [Effects of aloe extracts, aloctin A, on gastric secretion and on experimental gastric lesions in rats]

AU: Saito-H; Imanishi-K; Okabe-S

SO: Yakugaku-Zasshi. 1989 May; 109(5): 335-9

ISSN: 0031-6903

LA: JAPANESE; NON-ENGLISH

AB: Effect of aloctin A, glycoprotein isolated from leaves of Aloe arborescens MILL, on gastric secretion and on acute gastric lesions in rats were examined. Aloctin A given intravenously dose-dependently inhibited the volume of gastric juice, acid and pepsin output in pylorus-ligated rats. Aloctin A given intravenously significantly inhibited the development of Shay ulcers and indomethacin-induced gastric lesions in rats. It also inhibited water-immersion stress lesions induced in pylorus-ligated rats.

AN: 90172180

MEDLINE EXPRESS (R) 1984-1990 13 of 324

TI: Non-epileptic myoclonus and mitochondrial encephalomyopathy.

AU: Cukiert-A; Naylor-FG; Scapolan-HB; Vilela-MM; Aloe-FS; Siffert-JO; Tsanaclis-AM; Haddad-M; Machado-TC; Carvalho-Alegro-M; et-al

AD: Faculty of Medicine, University of Sao Paulo, Brasil.

SO: Arq-Neuropsiquiatr. 1989 Sep; 47(3): 346-51

This title is owned by this library

ISSN: 0004-282X

LA: ENGLISH

AB: Two brothers presented to us with a progressive myoclonic syndrome with slight cerebellar symptoms. Neurological examination disclosed moderate cerebellar signs and pale optic discs; asymmetric, asynchronous and arrhythmic myoclonus, an arrthesthesic deficit and no muscular weakness. EEG background activity was moderately slow with no irritative discharges. CT was normal in both cases. Intermittent photic stimulation increased the frequency of the myoclonic jerks, which became bilateral and synchronous, progressing to a generalized tonic-clonic seizure. EPs and MRI in one case were normal. Anticonvulsant drugs were ineffective. The diagnosis of mitochondrial encephalomyopathy was based on the finding, in muscle specimens, of thickened basement membranes with myofibrillary degeneration and increased number of mitochondria peripherally distributed and with a dense granular matrix and some vacuoles. The clinical and EEG data suggest a subcortical origin for this type of myoclonic syndrome.

AN: 90147107

MEDLINE EXPRESS (R) 1984-1990 14 of 324

TI: An anti-complementary polysaccharide with immunological adjuvant activity from the leaf parenchyma gel of Aloe vera.

AU: t'Hart-LA; van-den-Berg-AJ; Kuis-L; van-Dijk-H; Labadie-RP

SO: Planta-Med. 1989 Dec; 55(6): 509-12

This title is owned by this library

ISSN: 0032-0943

LA: ENGLISH

AB: The aim of the study is to develop new substances with immunomodulatory activity. To this end, extracts from plants used in traditional medicine are used as starting material. This study deals with the mucilagenous leaf-gel of Aloe vera which is well reputed for its therapeutical effect on inflammatory-based disorders. The purification of an aqueous gel-extract guided by inhibition of complement activity in HPS is described. Using anion-exchange and gel permeation chromatography a highly active polysaccharide fraction was isolated, that is present in the gel in various chain lengths. The polysaccharides consist of several monosaccharides of which mannose is dominant. The inhibition is based on alternative pathway activation, resulting in consumption of C3. With respect to their biological activity the polysaccharides inhibit the opsonization of zymosan in HPS and display adjuvant activity on specific antibody production and the induction of delayed type hypersensitivity in mice.

AN: 90139301

MEDLINE EXPRESS (R) 1984-1990 15 of 324

TI: Aloe vera does not affect cutaneous erythema and blood flow following ultraviolet B exposure.

AU: Crowell-J; Hilsenbeck-S; Penneys-N

AD: Department of Dermatology, University of Miami School of Medicine, Florida.

SO: Photodermatol. 1989 Oct; 6(5): 237-9

This title is owned by this library

ISSN: 0108-9684

LA: ENGLISH

AN: 90138468

MEDLINE EXPRESS (R) 1984-1990 16 of 324

TI: Wound healing. Oral and topical activity of Aloe vera.

AU: Davis-RH; Leitner-MG; Russo-JM; Byrne-ME

SO: J-Am-Podiatr-Med-Assoc. 1989 Nov; 79(11): 559-62

ISSN: 8750-7315

LA: ENGLISH

AB: The influence of Aloe vera, orally and topically, on wound healing was studied. Wounds were induced on both sides of the vertebral column of ICR mice using a biopsy punch. For the oral study, experimental animals received A. vera in their drinking water for 2 months, whereas the control animals received only water. In the topical study, experimental animals were given 25% A. vera in Eucerin cream topically. The control animals received cream only. A 62.5% reduction in wound diameter was noted in mice receiving 100 mg/kg/day oral A. vera and a 50.8% reduction was recorded in animals receiving topical 25% A. vera. These data suggest that A. vera is effective by both oral and topical routes of administration.

AN: 90112031

MEDLINE EXPRESS (R) 1984-1990 17 of 324

TI: NGF primed spleen cells injected in brain of developing rats differentiate into mast cells.

AU: Aloe-L; De-Simone-R

AD: Institute of Cell Biology, C.N.R., Rome, Italy.

SO: Int-J-Dev-Neurosci. 1989; 7(6): 565-73

This title is owned by this library

ISSN: 0736-5748

LA: ENGLISH

AB: The aim of this work was to study the topographic distribution and the morphological behaviour of nerve growth factor (NGF) primed spleen cells injected into the lateral ventricles of developing rat brain. Serial coronal brain sections showed that these transplanted cells acquire phenotypical characteristics similar to those of mast cells (MCs) and that they enhance local neovascularization. These results, together with the observation that these cells are located in proximity to the hippocampus, a brain tissue which contains one of the highest levels of NGF, provide a model for studying the relationship between NGF and MC differentiation and secretion.

AN: 90101992

MEDLINE EXPRESS (R) 1984-1990 18 of 324

TI: [Effect of drug preparations in vitro on the morphofunctional status of spermatozoa]

TO: Vliianie nekotorykh lekarstvennykh preparatov in vitro na morfofunktsional'noe sostoianie spermatozoonov.

AU: Israilov-SR

SO: Vrach-Delo. 1989 Aug(8): 52-4

ISSN: 0049-6804

LA: RUSSIAN; NON-ENGLISH

AB: The effect was studied of different drugs (aloe extract, penicillin, vitreous body and lidase) in 20 specimens of the ejaculate with established normozoospermia and in 20 specimens with oligozoospermia, asthenozoospermia and hypozoospermia. Experiments were carried out at +4 degrees C to -38 degrees C, every 2 hours for 72 hours. It was established that depending on the time, temperature and drugs there was an essential difference between the percent of mobility and ultrastructure of spermatozoa. The most favourable effect on spermatozoa was produced by temperature ranges from 11 to 18 degrees C, lidase and penicillin.

AN: 90070580

MEDLINE EXPRESS (R) 1984-1990 19 of 324

TI: [Chronic benign familial pemphigus]

TO: Khronicheskaia dobrokachestvennaia semeinaia puzyrchatka.

AU: Kovalev-VM; Tkachenko-LA; Krivenko-ZF; Stefanovskaia-LP

SO: Vestn-Dermatol-Venerol. 1989(8): 65-7

ISSN: 0042-4609

LA: RUSSIAN; NON-ENGLISH

AB: A female patient aged 50 is described, in whom candidiasis of the large folds has been erroneously diagnosed for 10 years; the diagnosis has not been confirmed by bacteriologic analysis, the therapy has been ineffective, the recurrences developed every year. The patient has developed symmetrical erythematous infiltrative areas in the armpits, groin, and in the folds under mammary glands, with solitary bullae up to 0.5-1.0 cm in diameter, with transparent contents, with thin flaccid covers and fragments thereof, as well as small pigmented vegetation. Basing on the histologic findings (suprabasal vesicles above the basal layer, acantholysis in the epidermis, and negligible lymphocytic infiltrate in the derma), Gougerot-Hailey-Hailey's disease has been diagnosed. The familial nature of the disease could not be established. Therapy with diphenhydramine, methyluracil, dimocifon, aloe extract, and aniline dyes, administered for 20 days, has resulted in clinical cure.

AN: 90051784

MEDLINE EXPRESS (R) 1984-1990 20 of 324

TI: Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression.

AU: Spillantini-MG; Aloe-L; Alleva-E; De-Simone-R; Goedert-M; Levi-Montalcini-R

AD: Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom.

SO: Proc-Natl-Acad-Sci-U-S-A. 1989 Nov; 86(21): 8555-9

This title is owned by this library

ISSN: 0027-8424

LA: ENGLISH

AB: The effects of intermale aggressive behavior induced by social isolation on the level of nerve growth factor (NGF) mRNA and protein were investigated in central and peripheral mouse tissues. A large increase in NGF mRNA and protein was observed in hypothalamus, with no changes in cerebral cortex, hippocampus, and cerebellum. No change in NGF mRNA levels was found in heart, spleen, vas deferens, and submaxillary salivary gland. The cellular localization of NGF mRNA in the central nervous system was investigated by in situ hybridization. Numerous nerve cells were specifically labeled in preoptic and ventrolateral nuclei of the hypothalamus, as well as in the cornu ammonis region of the hippocampus and throughout all layers of the cerebral cortex, with the highest concentration in layer III. The present results firmly establish that nerve cells constitute the major source in NGF in the brain. They also open the way to understanding the regulation of NGF biosynthesis in the central nervous system.

AN: 90046836

MEDLINE EXPRESS (R) 1984-1990 21 of 324

TI: Processed Aloe vera administered topically inhibits inflammation.

AU: Davis-RH; Rosenthal-KY; Cesario-LR; Rouw-GA

SO: J-Am-Podiatr-Med-Assoc. 1989 Aug; 79(8): 395-7

ISSN: 8750-7315

LA: ENGLISH

AB: Aloe vera preparations were evaluated for topical anti-inflammatory activity using the croton oil-induced edema assay. The results show that small amounts of A. vera given topically will inhibit inflammation induced by a moderate amount of irritant. In general, the decolorized Aloe was more effective than the colorized Aloe (with anthraquinone). A 47.1% inhibition of inflammation was obtained by 5% decolorized irradiated Aloe. These results may be used as a baseline to assess the biologic activity of A. vera in the treatment of inflammation by podiatric physicians.

AN: 90040137

MEDLINE EXPRESS (R) 1984-1990 22 of 324

TI: [Rehabilitation of patients with ulcers under hospital conditions]

TO: Reabilitatsiia bol'nykh iazvennoi bolezn'iu v statsionarnykh usloviiakh.

AU: Kovalenko-MF; Dergachev-BP

SO: Voen-Med-Zh. 1989 Jun(6): 29-30

ISSN: 0026-9050

LA: RUSSIAN; NON-ENGLISH

AN: 90021263

MEDLINE EXPRESS (R) 1984-1990 23 of 324

TI: Anti-inflammatory activity of Aloe vera against a spectrum of irritants.

AU: Davis-RH; Leitner-MG; Russo-JM; Byrne-ME

SO: J-Am-Podiatr-Med-Assoc. 1989 Jun; 79(6): 263-76

ISSN: 8750-7315

LA: ENGLISH

AB: The authors have evaluated the spectrum of anti-inflammatory activity of A. vera in a number of models of inflammation in the hind paw of the experimental rat induced by kaolin, carrageenan, albumin, dextran, gelatin, and mustard. Croton oil was used in a topical model of inflammation to determine the oral activity and time-dependent dosing of A. vera. The authors found that A. vera was active in all models of inflammation. Of the various irritants tested, A. vera was especially active against gelatin-induced and kaolin-induced edema and, in contrast, had minimal activity when tested against dextran-induced edema. Oral activity of A. vera was demonstrated to be dependent on the presence of anthraquinones. The various irritant-induced edema models provided a broad spectrum of anti-inflammatory activity for A. vera.

AN: 89311023

MEDLINE EXPRESS (R) 1984-1990 24 of 324

TI: [Studies on chemical protectors against radiation. XXVI. Protective effect of various extracts on crude drugs on skin injury induced by X-irradiation]

AU: Sato-Y; Ohta-S; Sakurai-N; Shinoda-M

SO: Yakugaku-Zasshi. 1989 Feb; 109(2): 113-8

ISSN: 0031-6903

LA: JAPANESE; NON-ENGLISH

AB: The protective potency against skin injury on mice induced by X-irradiation was studied by use of 72 extracts of crude drugs. The protective potency was determined according to the degrees on skin injury after irradiation of 1100R, 30 k Vp soft X-ray. As a result of these study, 16 kinds of crude drugs such as Rosae Fructus, Aloe arborescens (Herba), Citri Leiocarpae Exocarpium, Schizonepetae Spica, Evodiae Fructus, Bupleuri Radix, Corni Fructus, Perillae Herba, Anemarrhenae Rhizoma, Menthae Herba, Trapae Fructus, Angelicae Dahuricae Radix, Sinomeni Caulis et Rhizoma, Ephedrae Herba, Acer nikoense (Cortex), Forsythiae Fructus, revealed protective potencies on skin injury.

AN: 89310978

MEDLINE EXPRESS (R) 1984-1990 25 of 324

TI: [Primary screening of the immunopharmacologic activity of Filatov tissue therapy preparations]

TO: Pervichnyi skrining immunofarmakologicheskoi aktivnosti preparatov tkanevoi terapii po V.P. Filatovu.

AU: Degtiarenko-TV; Ivanova-AS; Skvortsov-VIu; Masternak-TV; Larin-AS

SO: Oftalmol-Zh. 1989(1): 34-9

ISSN: 0030-0675

LA: RUSSIAN; NON-ENGLISH

AB: The paper presents results of primary assessment of immunopharmacologic activity of tissue preparations (peloidodistillate, FiBS, torfot, extract of aloe, placental extract) and the study of their influence on basic links of immune response (experimental investigations were carried out with mice-hybrids F1). It is found that the studied bioregulators possess immunomodulating action on primary humoral immune response and don't increase a hypersensitive reaction of a slowed type. The direction of immunotropic action of tissue preparations depends on the state of immunologic reactivity of the body and the kind of a preparation (variety of immunopharmacologic activity of the distillates groups and albumin preparations). It is expedient to work out indications to the usage of tissue preparations after V. P. Filatov to prevent and treat immunodeficient and immunopathologic conditions of the body.

AN: 89282099

MEDLINE EXPRESS (R) 1984-1990 26 of 324

TI: [Experience using antihypoxic drugs in the treatment of acute neurosensory hearing loss in children with meningitis]

TO: Opyt primeneniia antigipoksantov v lechenii ostroi neirosensornoi tugoukhosti pri meningitakh u detei.

AU: Ryndina-AM; Lin'kov-VI; Dadiomova-MA; Buriakova-AV

SO: Vestn-Otorinolaringol. 1989 Mar-Apr(2): 14-7

This title is owned by this library

ISSN: 0042-4668

LA: RUSSIAN; NON-ENGLISH

AB: This paper describes beneficial affects of the therapy of neurosensory hypoacusia that complicated such neuroinfectious diseases as meningococcemia, meningococcic meningitis and meningitides of other etiology using traditional drugs (ATP, aloe, B and C vitamins) in combination with the antihypoxic agent gutimine and its analog. Positive effects were recorded in 17 (81%) out of 21 children. It is indicated that the agent shows higher efficacy when used within the first weeks after the onset of the disease.

AN: 89268134

MEDLINE EXPRESS (R) 1984-1990 27 of 324

TI: Aloe vera and burn wound healing [letter]

AU: Kaufman-T; Newman-AR; Wexler-MR

SO: Plast-Reconstr-Surg. 1989 Jun; 83(6): 1075-6

This title is owned by this library

ISSN: 0032-1052

LA: ENGLISH

AN: 89265229

MEDLINE EXPRESS (R) 1984-1990 28 of 324

TI: Aloe vera and gibberellin. Anti-inflammatory activity in diabetes.

AU: Davis-RH; Maro-NP

SO: J-Am-Podiatr-Med-Assoc. 1989 Jan; 79(1): 24-6

ISSN: 8750-7315

LA: ENGLISH

AB: Aloe vera inhibits inflammation and adjuvant-induced arthritis. The authors' laboratory has shown that A. vera improves wound healing, which suggests that it does not act like an adrenal steroid. Diabetic animals were used in this study because of their poor wound healing and anti-inflammatory capabilities. The anti-inflammatory activity of A. vera and gibberellin was measured in streptozotocin-induced diabetic mice by measuring the inhibition of polymorphonuclear leukocyte infiltration into a site of gelatin-induced inflammation over a dose range of 2 to 100 mg/kg. Both Aloe and gibberellin similarly inhibited inflammation in a dose-response manner. These data tend to suggest that gibberellin or a gibberellin-like substance is an active anti-inflammatory component in A. vera.

AN: 89258381

MEDLINE EXPRESS (R) 1984-1990 29 of 324

TI: [Purification, glucose-6-phosphate dehydrogenase inhibition, and HPLC analysis of four 1,8-dihydroxyanthrones]

TO: Reindarstellung, Glucose-6-phosphat-Dehydrogenase-Hemmung und HPLC-Analytik von vier 1,8-Dihydroxyanthronen.

AU: Rychener-M; Steiger-W

SO: Pharm-Acta-Helv. 1989; 64(1): 8-15

This title is owned by this library

ISSN: 0031-6865

LA: GERMAN; NON-ENGLISH

AB: With regard to the examination of their antipsoriatic properties, four 1,8-dihydroxyanthrones were prepared in a purity greater than 99%: Dithranol (1, anthralin) by chromatographic purification, chrysarobin (2) either by work-up from commercial chrysarobin or by an oxidative cleavage (FeCl3) of aloin, followed by a reduction (SnCl2/HCl) of the produced anthraquinone derivative (6), aloe emodin anthrone (3) by the action of aquous sodium tetraborate on aloin and frangula emodin anthrone (4) by the SnCl2/HCl-reduction of frangula emodin (7) isolated from the dry extract of the bark of alder buckthorn. UV/VIS, IR, 1H-NMR and mass spectra confirmed the structures of the four anthrones which all distinctly inhibited G-6-P dehydrogenase (0.05 mmol, desactivation in 6 h). For clinical studies the anthrones were incorporated into white petrolatum with exclusion of oxygen (under Ar). The anthrone content of the preparations was determined by HPLC (LiChrosorb RP-18, 7 microns [280 x 4 mm]; 1.5 ml/min MeOH/water/HOAc [80:20:0.2]) after extraction with CH2Cl2 (tR = 1: 10.4 min, 2: 15.3 min, 3: 4.7 min, 4: 7.7 min).

AN: 89240828

MEDLINE EXPRESS (R) 1984-1990 30 of 324

TI: Aloe vera, salicylic acid, and aspirin for burns [letter]

AU: Frumkin-A

SO: Plast-Reconstr-Surg. 1989 Jan; 83(1): 196

This title is owned by this library

ISSN: 0032-1052

LA: ENGLISH

AN: 89071995

MEDLINE EXPRESS (R) 1984-1990 31 of 324

TI: Aloe vera for burns [letter]

AU: Kivett-WF

SO: Plast-Reconstr-Surg. 1989 Jan; 83(1): 195

This title is owned by this library

ISSN: 0032-1052

LA: ENGLISH

AN: 89071993

MEDLINE EXPRESS (R) 1984-1990 32 of 324

TI: Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis.

AU: Hogan-DJ

AD: Department of Medicine, University of Saskatchewan, Saskatoon.

SO: CMAJ. 1988 Feb 15; 138(4): 336-8

ISSN: 0820-3946

LA: ENGLISH

AN: 88109174

MEDLINE EXPRESS (R) 1984-1990 33 of 324

TI: Two functionally and chemically distinct immunomodulatory compounds in the gel of Aloe vera.

AU: 't-Hart-LA; van-Enckevort-PH; van-Dijk-H; Zaat-R; de-Silva-KT; Labadie-RP

AD: Department of Chemical Pharmacy, Faculty of Pharmacy, State University of Utrecht, The Netherlands.

SO: J-Ethnopharmacol. 1988 May-Jun; 23(1): 61-71

This title is owned by this library

ISSN: 0378-8741

LA: ENGLISH

AB: An aqueous extract of Aloe vera gel was analyzed guided by modulatory activity with regard to the in vitro activation of human complement and of human polymorphnuclear leucocytes (PMN). Upon ultrafiltration a high (h-Mr) and a low (l-Mr) molecular mass fraction were obtained. Pre-incubation of human pooled serum with the h-Mr fraction resulted in a depletion of classical and alternative pathway complement activity. In contrast, only the l-Mr fraction could inhibit the production of free oxygen radicals by activated PMNs. The latter activity cannot be attributed to non-specific effects like toxicity, interference with stimulant binding or scavenger activity.

AN: 88333893

MEDLINE EXPRESS (R) 1984-1990 34 of 324

TI: Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn).

AU: Womble-D; Helderman-JH

AD: Renal Immunology Laboratory, University of Texas Southwestern Medical Center, Dallas.

SO: Int-J-Immunopharmacol. 1988; 10(8): 967-74

ISSN: 0192-0561

LA: ENGLISH

AB: Healing powers have been imputed as being a feature of the gel from the aloe vera plant for centuries. The recent isolation of the active ingredient, acemannan, has made testing of this drug important. Since the drug appears to enhance monocyte function in other experiments, these studies were designed to test the capacity of acemannan to enhance immune response to alloantigen and to test whether the potential enhancement is a monocyte driven phenomenon. Acemannan did not enhance lymphocyte response to syngeneic antigens in the mixed lymphocyte culture (MLC) but importantly increased alloantigenic response in a dose-response fashion (2.6 x 10(-7) - 2.6 x 10(-9)M). This effect of acemannan was shown to be a specific response and to concur with concentrations of in vitro acemannan achievable in vivo. A separate series of mixing experiments demonstrated that acemannan incubation with monocytes permitted monocyte driven signals to enhance T-cell response to lectin. It is concluded that acemannan, the active ingredient of the aloe vera plant, is an important immunoenhancer in that it increases lymphocyte response to alloantigen. It is suggested that the mechanism involves enhancement of monocyte release of IL-I under the aegis of alloantigen. This mechanism may explain in part the recently observed capacity of acemannan to abrogate viral infections in animal and man.

AN: 89108677

MEDLINE EXPRESS (R) 1984-1990 35 of 324

TI: Acute non lymphoid leukemia treatment: an update.

AU: Mandelli-F; Petti-MC; Aloe-Spiriti-MA

SO: Haematologica. 1988 Jan-Feb; 73(1): 1-6

This title is owned by this library

ISSN: 0390-6078

LA: ENGLISH

AN: 88226191

MEDLINE EXPRESS (R) 1984-1990 36 of 324

TI: Aloe vera [published erratum appears in J Am Acad Dermatol 1988 Jul;19(1 Pt 1):82]

AU: Klein-AD; Penneys-NS

AD: Department of Dermatology, University of Miami School of Medicine, FL.

SO: J-Am-Acad-Dermatol. 1988 Apr; 18(4 Pt 1): 714-20

This title is owned by this library

ISSN: 0190-9622

LA: ENGLISH

AB: We review the scientific literature regarding the aloe vera plant and its products. Aloe vera is known to contain several pharmacologically active ingredients, including a carboxypeptidase that inactivates bradykinin in vitro, salicylates, and a substance(s) that inhibits thromboxane formation in vivo. Scientific studies exist that support an antibacterial and antifungal effect for substance(s) in aloe vera. Studies and case reports provide support for the use of aloe vera in the treatment of radiation ulcers and stasis ulcers in man and burn and frostbite injuries in animals. The evidence for a potential beneficial effect associated with the use of aloe vera is sufficient to warrant the design and implementation of well-controlled clinical trials.

AN: 88228558

MEDLINE EXPRESS (R) 1984-1990 37 of 324

TI: [Studies of aloe. II. Mechanism of cathartic effect]

AU: Ishii-Y; Tanizawa-H; Takino-Y

SO: Yakugaku-Zasshi. 1988 Sep; 108(9): 904-10

ISSN: 0031-6903

LA: JAPANESE; NON-ENGLISH

AN: 89236055

MEDLINE EXPRESS (R) 1984-1990 38 of 324

TI: Metabolism of barbaloin by intestinal bacteria.

AU: Hattori-M; Kanda-T; Shu-YZ; Akao-T; Kobashi-K; Namba-T

SO: Chem-Pharm-Bull-Tokyo. 1988 Nov; 36(11): 4462-6

This title is owned by this library

ISSN: 0009-2363

LA: ENGLISH

AN: 89230603

MEDLINE EXPRESS (R) 1984-1990 39 of 324

TI: The influence of selected potential oncostatics of plant origin on the protein biosynthesis in vitro.

AU: Paszkiewicz-Gadek-A; Chlabicz-J; Galasinski-W

AD: Department of General and Organic Chemistry, Medical Academy, Bialystok, Poland.

SO: Pol-J-Pharmacol-Pharm. 1988 Mar-Apr; 40(2): 183-90

This title is owned by this library

ISSN: 0301-0244

LA: ENGLISH

AB: Five potential oncostatics of plant origin (reserpine, amphotericin B, rutoside, digoxin, dry aloe extract), and cyclic AMP were investigated for their effect on protein synthesis. The solutions of digoxin and dry aloe extract inhibited protein biosynthesis in vitro. The direct inhibiting effect of digoxin on the ribosomes suggests that this drug forms an inactive complex with this organelle. Therefore it can be concluded that ribosome is the target site of digoxin action. Aloin and aloeemodin are responsible for the inhibitory effect of the solution of dry aloe extract. They inhibit markedly [14C]-leucine incorporation into proteins. Aloin and aloeemodin do not influence directly the ribosomes, but they inhibit elongation factors and peptidyltransferase activities in the complete elongation system. Some preliminary experiments have shown that direct interaction between these substances and elongation factor EF-2 should be taken in account. This observation is the subject of further experiments, in which the characteristics of the inhibitory effect of the components isolated from dry aloe extract will be performed.

AN: 89184031

MEDLINE EXPRESS (R) 1984-1990 40 of 324

TI: Aloe vera. A natural approach for treating wounds, edema, and pain in diabetes.

AU: Davis-RH; Leitner-MG; Russo-JM

SO: J-Am-Podiatr-Med-Assoc. 1988 Feb; 78(2): 60-8

ISSN: 8750-7315

LA: ENGLISH

AN: 88214684

MEDLINE EXPRESS (R) 1984-1990 41 of 324

TI: Aloe vera gel hindered wound healing of experimental second-degree burns: a quantitative controlled study.

AU: Kaufman-T; Kalderon-N; Ullmann-Y; Berger-J

AD: Faculty of Medicine, Technion-Israel Institute of Technology, Israel.

SO: J-Burn-Care-Rehabil. 1988 Mar-Apr; 9(2): 156-9

ISSN: 0273-8481

LA: ENGLISH

AB: In the present study, Aloe vera gel (AVG) was applied to experimental second-degree burns in guinea pigs, and its effects on epithelialization, wound contraction, newly formed granulation tissue, and regeneration of hair follicles was compared with that effected by 1% silver sulfadiazine cream (AgSD). Epithelialization (%mean +/- SEM) on postburn day 8, 16, and 24 of the AVG-treated wounds was 38.72% +/- 2.71%, 60.34% +/- 3.28%, and 92.46% +/- 2.26%, respectively, while that of the AgSD-treated burns was 53.35% +/- 2.65%, 94.84% +/- 2.65%, and 100%, respectively (P less than .001). Contraction of the AVG-wounds was significantly higher than that of the AgSD-treated burns during 24 days of the study (P less than .001). The thickness of the newly formed granulation tissue was higher in the AVG-treated wounds (P less than .001), while the hair follicles count was significantly lower (P less than .001) compared with the AgSD-treated burns. It is concluded that this preparation of Aloe vera gel hindered the healing process of the present burn wound model when compared with 1% silver sulfadiazine cream.

AN: 88198281

MEDLINE EXPRESS (R) 1984-1990 42 of 324

TI: The effect of nerve growth factor and its antibody on mast cells in vivo.

AU: Aloe-L

AD: Istituto di Neurobiologia, C.N.R., Rome, Italy.

SO: J-Neuroimmunol. 1988 Apr; 18(1): 1-12

This title is owned by this library

ISSN: 0165-5728

LA: ENGLISH

AB: Repeated subcutaneous administration of nerve growth factor (NGF) into newborn rats caused an increase in number and size of free and tissue-adherent mast cells (MCs). In vivo and in vitro autoradiographic studies show that MCs exhibit specific binding sites for NGF. Peritoneal MCs of adult rats exposed to high titers of endogenous (autoimmunization) and exogenous NGF antibodies showed severe cytological alterations and decreased in number. Light and electron microscopic studies revealed that MC destruction took place slowly (7-10 days) and required continual exposure to high titers of NGF antibodies. The role played by NGF in the hematopoietic cell lineage is at present under study in our laboratory.

AN: 88154057

MEDLINE EXPRESS (R) 1984-1990 43 of 324

TI: Comparative evaluation of aloe vera in the management of burn wounds in guinea pigs.

AU: Rodriguez-Bigas-M; Cruz-NI; Suarez-A

AD: Surgical Research Laboratories, University of Puerto Rico School of Medicine, San Juan.

SO: Plast-Reconstr-Surg. 1988 Mar; 81(3): 386-9

This title is owned by this library

ISSN: 0032-1052

LA: ENGLISH

AB: An experimental study was designed using Hartley guinea pigs, who received full-thickness burns covering 3 percent of their body surface area by direct contact with a hot plate. A total of 40 animals were equally divided among four modalities of closed burn wound management as follows: group I: silver sulfadiazine (Silvadine); group II: aloe vera gel extract (Carrington Dermal Wound Gel); group III: salicylic acid cream (aspirin); and group IV: plain gauze occlusive dressing only. The dressings were changed daily, and the size and appearance of each burn wound were recorded until complete healing. On the sixth postburn day, quantitative burn wound cultures were made. The average time to complete healing in the control group was 50 days, and the only significant difference was found in the aloe vera-treated animals, which healed on an average of 30 days (p less than 0.02). Wound bacterial counts were effectively decreased by silver sulfadiazine (p = 0.015) and by aloe vera extract (p = 0.015). From our data it appears that aloe gel extracts permit a faster healing of burn wounds.

AN: 88125468

MEDLINE EXPRESS (R) 1984-1990 44 of 324

TI: The role of thromboxane in experimental inadvertent intra-arterial drug injections.

AU: Zachary-LS; Smith-DJ Jr; Heggers-JP; Robson-MC; Boertman-JA; Niu-XT; Schileru-RE; Sacks-RJ

SO: J-Hand-Surg-Am. 1987 Mar; 12(2): 240-5

This title is owned by this library

ISSN: 0363-5023

LA: ENGLISH

AB: Inadvertent intra-arterial injection of drugs produces a well-defined clinical syndrome whose pathophysiology remains unclear. This study was designed to determine the role of the inflammatory mediator, thromboxane, in intra-arterial drug injections. The rabbit ear model, as described by Kinmonth and Sheppard, was used. Five of the experimental groups were treated with specific or nonspecific thromboxane blocking agents and two groups served as controls. Immunohistochemical staining of the control ears showed elevated levels of thromboxane within the first 6 hours postinjury. The specific thromboxane blocking agents, methimazole and Aloe vera, showed almost complete blockade of thromboxane production. The percentage of ear survival was significantly greater in the group treated with topical Aloe vera (p less than 0.05) and even greater survival was achieved in the combined Aloe vera/methimazole group (p less than 0.01). On the basis of these results, we have begun treatment of such injuries with specific and nonspecific thromboxane blocking agents.

AN: 87167320

MEDLINE EXPRESS (R) 1984-1990 45 of 324

TI: The detection of laxative abuse.

AU: Morton-J

SO: Ann-Clin-Biochem. 1987 Jan; 24 ( Pt 1): 107-8

This title is owned by this library

ISSN: 0004-5632

LA: ENGLISH

AN: 87155129

MEDLINE EXPRESS (R) 1984-1990 46 of 324

TI: Dermabrasion-Loo-punch-excision technique for the treatment of acne-induced osteoma cutis.

AU: Fulton-JE Jr

SO: J-Dermatol-Surg-Oncol. 1987 Jun; 13(6): 655-9

This title is owned by this library

ISSN: 0148-0812

LA: ENGLISH

AB: Three patients with chronic osteoma cutis secondary to acne vulgaris were treated with the dermabrasion-Loo-punch-excision technique. Under regional nerve block with lidocaine-bipuvacaine (50:50) a uniform dermabrasion was performed across the entire face, including the hairline and 1 cm below the jawline. This exposed the foci of osteoma cutis. Then the appropriate sized Loo punch (usually the 2.0- or the 2.5-mm punch) was used to excise the bluish-gray miliary lesions. The majority of the foci were removed in one operation. Following excision, the lesions were closed with 7-0 prolene suture. To prevent crust formation postoperatively, Aloe-vera-soaked polyethylene oxide gel dressings (Vigilon) were changed twice daily following an ice water compress. Sutures were removed rapidly in 5 to 7 days to prevent the appearance of suture lines. Although one patient required an additional procedure, the cosmetic results were excellent. Only a few small residual blue "dot" lesions remained in these three cases.

AN: 87223433

MEDLINE EXPRESS (R) 1984-1990 47 of 324

TI: Intraocular herpes simplex virus injection in neonatal rats induces sympathetic nerve cell destruction: effect of nerve growth factor.

AU: Aloe-L

AD: Institute of Neurobiology, C.N.R., Rome, Italy.

SO: Int-J-Dev-Neurosci. 1987; 5(4): 357-66

This title is owned by this library

ISSN: 0736-5748

LA: ENGLISH

AB: The effect of herpes simplex virus (HSV) injection on the sympathetic nerve system of newborn rats was studied at structural, ultrastructural, and immunohistochemical levels. It was found that HSV injected into the anterior eye chamber is retrogradely transported and reaches the nerve cell bodies of the ipsilateral superior cervical ganglion (SCG) after 18-24 hr, causing complete cell destruction within 3-4 days. In subsequent days, nerve cells of the contralateral SCG, spinal sensory ganglia, chromaffin cells and brain cells also become infected and are eventually killed by the virus. Pretreatment with nerve growth factor (NGF) produces an initial protection from viral cell destruction, but does not block the final, lethal effect of the virus. These investigations demonstrate that sympathetic nerve cell destruction can be induced in newborn rodents by HSV, and that NGF treatment renders the cells, for a time-limited period, more resistant to the virus.

AN: 89022170

MEDLINE EXPRESS (R) 1984-1990 48 of 324

TI: Aloe vera and wound healing.

AU: Davis-RH; Kabbani-JM; Maro-NP

SO: J-Am-Podiatr-Med-Assoc. 1987 Apr; 77(4): 165-9

ISSN: 8750-7315

LA: ENGLISH

AN: 87225713

MEDLINE EXPRESS (R) 1984-1990 49 of 324

TI: Effect of amino acids in Aloe extract on phagocytosis by peripheral neutrophil in adult bronchial asthma.

AU: Yagi-A; Shida-T; Nishimura-H

SO: Arerugi. 1987 Dec; 36(12): 1094-101

ISSN: 0021-4884

LA: ENGLISH

AN: 88240045

MEDLINE EXPRESS (R) 1984-1990 50 of 324

TI: [Induction of lymphoblastic transformation by a polysaccharide extract of a native Madagascar plant Aloe vahombe: ALVA]

TO: Induction de la transformation lymphoblastique par un extrait polysaccharidique d'une plante endemique malgache l'Aloe vahombe: "l'ALVA".

AU: Ralamboranto-L; Rakotovao-LH; Coulanges-P; Corby-G; Janot-C; Le-Deaut-JY

AD: Universite de Madagascar, E.E.S. Sciences Antananarivo.

SO: Arch-Inst-Pasteur-Madagascar. 1987; 53(1): 227-31

This title is owned by this library

ISSN: 0020-2495

LA: FRENCH; NON-ENGLISH

AN: 88239878

MEDLINE EXPRESS (R) 1984-1990 51 of 324

TI: Topical anti-inflammatory activity of Aloe vera as measured by ear swelling.

AU: Davis-RH; Leitner-MG; Russo-JM

SO: J-Am-Podiatr-Med-Assoc. 1987 Nov; 77(11): 610-2

ISSN: 8750-7315

LA: ENGLISH

AN: 88172087

MEDLINE EXPRESS (R) 1984-1990 52 of 324

TI: CALLA-negative, TdT- and CD7-positive acute lymphoblastic leukemia: a phenotype associated with poor prognosis.

AU: De-Rossi-G; Aloe-Spiriti-MA; Cafolla-A; Gastaldi-R; Lo-Coco-F; Lopez-M; Luciani-M; Pasqualetti-D; Testi-AM; Mandelli-F

AD: Hematology Section of the Department of Human Biopathology, University La Sapienza, Rome, Italy.

SO: Diagn-Clin-Immunol. 1987; 5(3): 140-3

ISSN: 0895-0458

LA: ENGLISH

AB: Eight ALL patients displaying a CD7+, Tdt+, CD10-, T MoAbs-, myeloid MoAbs-, AP+ phenotype are described. Some patients showed well-known risk factors such as cytogenetic abnormalities, high WBC count, mediastinal mass, and/or organomegalies. The clinical behaviour was very poor and only one patient is in CR and off therapy. Therefore such a pre-T phenotype, although sometimes associated with the other risk factors, could be considered a poor prognosis phenotype.

AN: 88080877

MEDLINE EXPRESS (R) 1984-1990 53 of 324

TI: Nerve growth factor influences neurobehavioral development of newborn mice.

AU: Alleva-E; Aloe-L; Calamandrei-G

AD: Section of Neurobehavioral Pathophysiology, Laboratorio di Fisiopatologia di Organo, Roma, Italy.

SO: Neurotoxicol-Teratol. 1987 Jul-Aug; 9(4): 271-5

ISSN: 0892-0362

LA: ENGLISH

AB: Thirty-six male pups of the CD-1 outbred strain received from postnatal day 2 to day 10 a daily subcutaneous injection of either highly purified murine Nerve Growth Factor (NGF; 5 mg/kg), cytochrome c (5 mg/kg), or saline solution. NGF-treated pups showed a slight, but significant, reduction in body weight gain and a concomitant acceleration in the appearance of early signs of neurobehavioral maturation such as righting reflex, cliff aversion, and response to tactile stimulation of the perioral area. Other responses, including the ultrasonic vocalization pattern on day 7, were unaffected or affected to a lesser extent.

AN: 88065346

MEDLINE EXPRESS (R) 1984-1990 54 of 324

TI: Experimental and clinical observations on frostbite.

AU: Heggers-JP; Robson-MC; Manavalen-K; Weingarten-MD; Carethers-JM; Boertman-JA; Smith-DJ Jr; Sachs-RJ

SO: Ann-Emerg-Med. 1987 Sep; 16(9): 1056-62

ISSN: 0196-0644

LA: ENGLISH

AB: Experimental ischemia by the classic frostbite rabbit ear model clearly defined the role of thromboxane as a mediator of progressive dermal ischemia in frostbite injuries. The therapeutic groups consisted of the antiprostanoids, methylprednisolone, and aspirin combined with anti-thromboxane agents Aloe vera and methimazole, while the control group received no therapy. Survival was measured by planimetry for all groups. No tissue survival was evident in the frostbite control group. Methimazole treatment allowed 34.3% survival, Aloe vera 28.2% survival, aspirin 22.5% survival, and methylprednisolone 17.5% survival. The data compare the results of a modified frostbite protocol using ibuprofen with therapeutic modalities used by other clinical services. Of 154 patients treated for frostbite from 1982 to 1985, 56 were treated with our frostbite protocol; 98 were treated with other modalities. Of the 56 protocol patients, 18 suffered 1st degree frostbite, 25, 2nd degree frostbite, and 13, 3rd degree frostbite. For all degrees of frostbite, 67.9% healed without tissue loss, 25.0% healed with partial tissue loss, and 7% required amputation (P less than .001). Of the patients not on protocol, 11 suffered 1st degree frostbite, 51, 2nd degree frostbite, and 36, 3rd degree frostbite. Of these, 32.7% healed without tissue loss, 34.6% healed with tissue loss, and 32.7% required amputation. The morbidity of progressive dermal ischemia in frostbite may be decreased by the therapeutic use of inhibitors of the arachidonic acid cascade.

AN: 87324359

MEDLINE EXPRESS (R) 1984-1990 55 of 324

TI: Studies on the activity of individual plants of an antidiabetic plant mixture.

AU: Al-Awadi-FM; Gumaa-KA

SO: Acta-Diabetol-Lat. 1987 Jan-Mar; 24(1): 37-41

This title is owned by this library

ISSN: 0001-5563

LA: ENGLISH

AB: A blood glucose lowering extract of a mixture of five plants in use by Kuwaiti diabetics was studied for the identification of its active component(s). Only the extracts of myrrh and aloe gums effectively increased glucose tolerance in both normal and diabetic rats. The remaining components, gum olibanum, Nigella sativa seeds and gum assafoetida were without effect.

AN: 87294875

MEDLINE EXPRESS (R) 1984-1990 56 of 324

TI: Plant lectin, ATF1011, on the tumor cell surface augments tumor-specific immunity through activation of T cells specific for the lectin.

AU: Yoshimoto-R; Kondoh-N; Isawa-M; Hamuro-J

SO: Cancer-Immunol-Immunother. 1987; 25(1): 25-30

This title is owned by this library

ISSN: 0340-7004

LA: ENGLISH

AB: The possibility that a plant lectin as a carrier protein would specifically activate T cells, resulting in the augmentation of antitumor immunity was investigated. ATF1011, a nonmitogenic lectin for T cells purified from Aloe arborescens Mill, bound equally to normal and tumor cells. ATF1011 binding on the MM102 tumor cell surfaces augmented anti-trinitrophenyl (TNP) antibody production of murine splenocytes when the mice were primarily immunized with TNP-conjugated MM102 tumor cells. The alloreactive cytotoxic T cell response was also augmented by allostimulator cells binding ATF1011 on the cell surfaces. These augmented responses may be assumed to be mediated by the activation of helper T cells recognizing ATF1011 as a carrier protein. Killer T cells were induced against ATF1011 antigen in the H-2 restricted manner using syngeneic stimulator cells bearing ATF1011 on the cell surfaces. When this lectin was administered intralesionally into the tumors, induction of cytotoxic effector cells was demonstrated. These results suggest that intralesionally administered ATF1011 binds to the tumor cell membrane and activates T cells specific for this carrier lectin in situ, which results in the augmented induction of systemic antitumor immunity.

AN: 87244147

MEDLINE EXPRESS (R) 1984-1990 57 of 324

TI: Separation and quantitation of fatty acids, sterols and bile acids in feces by gas chromatography as the butyl ester-acetate derivatives.

AU: Child-P; Aloe-M; Mee-D

SO: J-Chromatogr. 1987 Mar 20; 415(1): 13-26

This title is owned by this library

ISSN: 0021-9673

LA: ENGLISH

AB: A system allowing the separation and quantitation of individual species of fecal fatty acids, sterols and bile acids in a single chromatographic step is described. The system is based on the butylation of carboxyl groups and acetylation of free hydroxyls of the compounds in fecal lipid extracts, followed by their resolution by temperature-programmed gas chromatography. As the butyl ester-acetate derivatives, fatty acids, sterols and bile acids elute separately and with no overlap on a variety of chromatographic columns, obviating the need for prior separation of each class by thin-layer or column chromatography. All common bile acids, a wide variety of sterols and keto-steroids, as well as saturated and unsaturated fatty acids may be routinely resolved. Quantitation is facilitated by the addition of the internal standards, heptadecanoic acid and nor-deoxycholic acid to each sample. With an automatic sample injector, the rapid assessment of a wide range of potential risk factors for colorectal cancer may be carried out in large numbers of samples.

AN: 87222849

MEDLINE EXPRESS (R) 1984-1990 58 of 324

TI: Lymphocutaneous sporotrichosis.

AU: Satta-S

SO: Hawaii-Med-J. 1987 Apr; 46(4): 124, 127

ISSN: 0017-8594

LA: ENGLISH

AN: 87221549

MEDLINE EXPRESS (R) 1984-1990 59 of 324

TI: Bradykinin-degrading glycoprotein in Aloe arborescens var. natalensis.

AU: Yagi-A; Harada-N; Shimomura-K; Nishioka-I

SO: Planta-Med. 1987 Feb; 53(1): 19-21

This title is owned by this library

ISSN: 0032-0943

LA: ENGLISH

AN: 87204669

MEDLINE EXPRESS (R) 1984-1990 60 of 324

TI: [Antimetastatic properties of aloe juice]

TO: Protivometastaticheskie svoistva soka aloe.

AU: Gribel'-NV; Pashinskii-VG

SO: Vopr-Onkol. 1986; 32(12): 38-40

This title is owned by this library

ISSN: 0507-3758

LA: RUSSIAN; NON-ENGLISH

AB: An evaluation of antimetastatic properties of succus Aloes was carried out using three types of experimental tumors of mice and rats. It was found that succus Aloes treatment contributes to reduction of tumor mass, metastatic foci and metastasis frequency at different stages of tumor progress without affecting major tumor growth. Succus Aloes potentiates the antitumor effect of 5-fluorouracil and cyclophosphamide as components of combination chemotherapy.

AN: 87095708

MEDLINE EXPRESS (R) 1984-1990 61 of 324

TI: The antidiabetic activity of aloes: preliminary clinical and experimental observations.

AU: Ghannam-N; Kingston-M; Al-Meshaal-IA; Tariq-M; Parman-NS; Woodhouse-N

SO: Horm-Res. 1986; 24(4): 288-94

This title is owned by this library

ISSN: 0301-0163

LA: ENGLISH

AB: The dried sap of the aloe plant (aloes) is one of several traditional remedies used for diabetes in the Arabian peninsula. Its ability to lower the blood glucose was studied in 5 patients with non-insulin-dependent diabetes and in Swiss albino mice made diabetic using alloxan. During the ingestion of aloes, half a teaspoonful daily for 4-14 weeks, the fasting serum glucose level fell in every patient from a mean of 273 +/- 25 (SE) to 151 +/- 23 mg/dl (p less than 0.05) with no change in body weight. In normal mice, both glibenclamide (10 mg/kg twice daily) and aloes (500 mg/kg twice daily) induced hypoglycaemia after 5 days, 71 +/- 6.2 and 91 +/- 7.6 mg/dl, respectively, versus 130 +/- 7 mg/dl in control animals (p less than 0.01); only glibenclamide was effective after 3 days. In the diabetic mice, fasting plasma glucose was significantly reduced by glibenclamide and aloes after 3 days. Thereafter only aloes was effective and by day 7 the plasma glucose was 394 +/- 22.0 versus 646 +/- 35.9 mg/dl, in the controls and 726 +/- 30.9 mg/dl in the glibenclamide treated group (p less than 0.01). We conclude that aloes contains a hypoglycaemic agent which lowers the blood glucose by as yet unknown mechanisms.

AN: 87055702

MEDLINE EXPRESS (R) 1984-1990 62 of 324

TI: The glucomannan system from Aloe vahombe (liliaceae). III. Comparative studies on the glucomannan components isolated from the leaves.

AU: Vilkas-E; Radjabi-Nassab-F

SO: Biochimie. 1986 Sep; 68(9): 1123-7

This title is owned by this library

ISSN: 0300-9084

LA: ENGLISH

AB: The polysaccharide mixture obtained by hot water extraction of Aloe vahombe leaves is composed of at least four different paritally acetylated glucomannans which differ in molecular weight, glucose to mannose ratios and acetyl contents. Furthermore, one fraction contains a small but significant amount of protein which could not be removed by gel filtration in a hydrogen-bond-breaking medium, by DEAE-Sephadex A-50 anion exchange chromatography, or by Sevag's method.

AN: 87049830

MEDLINE EXPRESS (R) 1984-1990 63 of 324

TI: Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream.

AU: Aloe-L; Alleva-E; Bohm-A; Levi-Montalcini-R

SO: Proc-Natl-Acad-Sci-U-S-A. 1986 Aug; 83(16): 6184-7

This title is owned by this library

ISSN: 0027-8424

LA: ENGLISH

AB: Intraspecific fighting induced by 6-8 weeks of social isolation results in massive release of nerve growth factor (NGF) into the bloodstream of adult male mice. The amount of circulating NGF is highly correlated with the number of fighting episodes. Biological, radioimmunological, immunohistochemical, and ultrastructural studies show that NGF is discharged from the salivary gland into the blood within minutes after fighting and reaches the highest level 3-4 hr later. Adrenergic innervation of the salivary gland or adrenalectomy does not abolish the NGF release. Corticotropic hormones do not induce NGF increase in the blood. Daily administrations of highly purified NGF (3 micrograms per g of body weight) result in a considerable increase in the volume of adrenal glands. These findings are unequivocable evidence for a physiological role of the mouse salivary glands as a major source of blood NGF.

AN: 86287420

MEDLINE EXPRESS (R) 1984-1990 64 of 324

TI: Evaluation of a polychemotherapeutic regimen including Idarubicin (4-demethoxydaunorubicin) in relapsed acute lymphocytic leukemia.

AU: Mandelli-F; Testi-AM; Aloe-Spiriti-MA; Giona-F; Meloni-G; Moleti-ML; Amadori-S; Pacciarini-MA

SO: Haematologica. 1986 Jan-Feb; 71(1): 34-8

This title is owned by this library

ISSN: 0390-6078

LA: ENGLISH

AN: 86193790

MEDLINE EXPRESS (R) 1984-1990 65 of 324

TI: [Bacterial flora in jejunal aspirates: study using culture examination, gas chromatography and H2 breath-test]

TO: La flora batterica nell'aspirato digiunale: indagini mediante esame colturale, gas-cromatografico e H2 breath-test.

AU: Menozzi-MG; Avanzini-P; Aloe-R; Cavalli-A; Chezzi-C; Corazza-GR; Strocchi-A; Rasciti-L; Gasbarrini-G

SO: Ann-Ist-Super-Sanita. 1986; 22(3): 759-62

This title is owned by this library

ISSN: 0021-2571

LA: ITALIAN; NON-ENGLISH

AN: 87154866

MEDLINE EXPRESS (R) 1984-1990 66 of 324

TI: [Effect of aloe on the resistance of the optic nerve system of the eye]

TO: Vliianie aloe na rezistentnost' zritel'no-nervnogo apparata glaza.

AU: Dumbrova-NE; Sotnikova-Ep; Gorianova-NA

SO: Oftalmol-Zh. 1986(8): 494-6

ISSN: 0030-0675

LA: RUSSIAN; NON-ENGLISH

AN: 87145550

MEDLINE EXPRESS (R) 1984-1990 67 of 324

TI: The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel.

AU: Grindlay-D; Reynolds-T

SO: J-Ethnopharmacol. 1986 Jun; 16(2-3): 117-51

This title is owned by this library

ISSN: 0378-8741

LA: ENGLISH

AB: The mucilaginous gel from the parenchymatous cells in the leaf pulp of Aloe vera has been used since early times for a host of curative purposes. This gel should be distinguished clearly from the bitter yellow exudate originating from the bundle sheath cells, which is used for its purgative effects. Aloe vera gel has come to play a prominent role as a contemporary folk remedy, and numerous optimistic, and in some cases extravagant, claims have been made for its medicinal properties. Modern clinical use of the gel began in the 1930s, with reports of successful treatment of X-ray and radium burns, which led to further experimental studies using laboratory animals in the following decades. The reports of these experiments and the numerous favourable case histories did not give conclusive evidence, since although positive results were usually described, much of the work suffered from poor experimental design and insufficiently large test samples. In addition some conflicting or inconsistent results were obtained. With the recent resurgence of interest in Aloe vera gel, however, new experimental work has indicated the possibility of distinct physiological effects. Chemical analysis has shown the gel to contain various carbohydrate polymers, notably either glucomannans or pectic acid, along with a range of other organic and inorganic components. Although many physiological properties of the gel have been described, there is no certain correlation between these and the identified gel components.

AN: 86309500

MEDLINE EXPRESS (R) 1984-1990 68 of 324

TI: Pretreatment of young mice with nerve growth factor enhances scopolamine-induced hyperactivity.

AU: Alleva-E; Aloe-L; Laviola-G

SO: Brain-Res. 1986 Aug; 393(2): 278-81

This title is owned by this library

ISSN: 0006-8993

LA: ENGLISH

AB: Twenty-one-day-old mice show a characteristic enhancement of locomotor activity upon injection of the cholinergic (muscarinic) blocking drug scopolamine. Intracerebral (third ventricle) injection of nerve growth factor (NGF) 24 h prior to scopolamine injection significantly enhances the drug-induced hyperactivity without modifying baseline activity. Such potentiation of the scopolamine effect was not obtained in 10-week-old mice treated and tested similarly.

AN: 86297605

MEDLINE EXPRESS (R) 1984-1990 69 of 324

TI: Wound care forum: Readers' remedies for pressure sores.

AU: Cuzzell-JZ

SO: Am-J-Nurs. 1986 Aug; 86(8): 923-4

This title is owned by this library

ISSN: 0002-936X

LA: ENGLISH

AN: 86293078

MEDLINE EXPRESS (R) 1984-1990 70 of 324

TI: Aloe vera, fiction or fact.

AU: Natow-AJ

SO: Cutis. 1986 Feb; 37(2): 106, 108

This title is owned by this library

ISSN: 0011-4162

LA: ENGLISH

AN: 86163412

MEDLINE EXPRESS (R) 1984-1990 71 of 324

TI: Antiarthritic activity of anthraquinones found in aloe for podiatric medicine.

AU: Davis-RH; Agnew-PS; Shapiro-E

SO: J-Am-Podiatr-Med-Assoc. 1986 Feb; 76(2): 61-6

ISSN: 8750-7315

LA: ENGLISH

AN: 86088605

MEDLINE EXPRESS (R) 1984-1990 72 of 324

TI: Isolation of a new aloe-emodin dianthrone diglucoside from senna and its potentiating effect on the purgative activity of sennoside A in mice.

AU: Nakajima-K; Yamauchi-K; Kuwano-S

SO: J-Pharm-Pharmacol. 1985 Oct; 37(10): 703-6

This title is owned by this library

ISSN: 0022-3573

LA: ENGLISH

AB: Two aloe-emodin dianthrone diglucosides (I and II) were isolated from the leaves of Cassia angustifolia Vahl by successive column chromatography with Amberlite XAD-2, silica gel, Polyamide C-200 and Sephadex LH-20. The stereostructures of I and II were elucidated as trans and meso isomers at 10-10', respectively, from the patterns of the ultraviolet absorption spectra and circular dichroism curves. This is the first report of isolation of diglucoside I from senna. Despite the lack of purgative activity, diglucoside I exerts a potentiating effect of about 1.3 times on the purgative activity of sennoside A in mice when even 15% is included in the mixture. The difference between I and a third active glycoside based on aloe-emodin is also discussed.

AN: 86088452

MEDLINE EXPRESS (R) 1984-1990 73 of 324

TI: Prevention of atheromatous heart disease.

AU: Agarwal-OP

SO: Angiology. 1985 Aug; 36(8): 485-92

This title is owned by this library

ISSN: 0003-3197

LA: ENGLISH

AB: Five thousand patients of atheromatous heart disease, presented as angina pectoris, were studied over a period of five years. After adding the 'Husk of Isabgol' and 'aloe vera' (an indigenous plant known as ghee-guar-ka-paththa) to the diet, a marked reduction in total serum cholesterol, serum triglycerides, fasting and post prandial blood sugar level in diabetic patients, total lipids and also increase in HDL were noted. Simultaneously the clinical profile of these patients showed reduction in the frequency of anginal attacks and gradually, the drugs, like verapamil, nifedipine, beta-blockers and nitrates, were tapered. The patients, most benefitted, were diabetics (without adding any antidiabetic drug). The exact mechanism of the action of the above two substances is not known, but it appears, that probably they act by their high fibre contents. Both these substances need further evaluation. The most interesting aspect of the study was that no untoward side effect was noted and all the five thousand patients are surviving till date.

AN: 85304965

MEDLINE EXPRESS (R) 1984-1990 74 of 324

TI: Topical effect of aloe with ribonucleic acid and vitamin C on adjuvant arthritis.

AU: Davis-RH; Shapiro-E; Agnew-PS

SO: J-Am-Podiatr-Med-Assoc. 1985 May; 75(5): 229-37

ISSN: 8750-7315

LA: ENGLISH

AN: 85236976

MEDLINE EXPRESS (R) 1984-1990 75 of 324

TI: Cyclocytidine-induced release of nerve growth factor from mouse submandibular glands enhances regeneration of sympathetic fibers in adult mice.

AU: Aloe-L; Cozzari-C; Levi-Montalcini-R

SO: Brain-Res. 1985 Apr 22; 332(2): 259-65

This title is owned by this library

ISSN: 0006-8993

LA: ENGLISH

AB: The injection of a drug endowed with the property of stimulating alpha-adrenergic receptors, cyclocytidine (Cyclo-C), produces drastic depletion of NGF from the granular convoluted tubules (GCT) of the mouse submaxillary salivary gland and a marked NGF level increase in the bloodstream. The NGF discharged from the gland gains access to the blood. Histological studies, immunohistochemistry, in vitro biological assays and radioimmunoassays gave evidence for the growth response elicited by the endogenously released salivary NGF in intact and surgically axotomized sympathetic ganglia. These results suggest that the mouse salivary NGF displays a biological activity on its target sympathetic nerve cells.

AN: 85200795

MEDLINE EXPRESS (R) 1984-1990 76 of 324

TI: [Evaluation of the effectiveness of long-term dispensary observation and treatment of patients with osteoarthrosis deformans]

TO: Otsenka effektivnosti dlitel'nogo dispansernogo nabliudeniia i lecheniia bol'nykh deformiruiushchim osteoartrozom.

AU: Burkhanova-PA

SO: Ter-Arkh. 1985; 57(8): 143-5

This title is owned by this library

ISSN: 0040-3660

LA: RUSSIAN; NON-ENGLISH

AB: During 1979-1984, 240 outpatients aged 30 to 65 years suffering from primary osteoarthrosis deformans with primary involvement of the knee joints were followed up. One of the dispensary groups consisted of 180 patients with osteoarthrosis deformans without synovitis, the other one of 60 patients with associated osteoarthrosis and synovitis. Prolonged follow up and repeated multiple modality treatment inhibited the progression of the pathological process, reduced the clinical and functional disease manifestations permitting the patients' work fitness to be preserved.

AN: 86071062

MEDLINE EXPRESS (R) 1984-1990 77 of 324

TI: Comparative effectiveness of topical treatments for hydrofluoric acid burns.

AU: Bracken-WM; Cuppage-F; McLaury-RL; Kirwin-C; Klaassen-CD

SO: J-Occup-Med. 1985 Oct; 27(10): 733-9

This title is owned by this library

ISSN: 0096-1736

LA: ENGLISH

AB: Hydrofluoric acid (HF) burns are characterized by progressive tissue necrosis and severe pain. Numerous topical treatments have been proposed, yet few have been studied experimentally. The present study was designed to examine the comparative efficacy of recommended treatments. Hair on the hind legs of rats was removed and 48 hours later 70% HF was applied. Calcium gluconate, Zephiran (benzalkonium chloride), A + D Ointment, aloe gel, and magnesium ointment were applied topically and burn development was monitored. Calcium gluconate significantly reduced burn size as early as one hour after application. Significant protection continued for seven days after the single application. The other treatments were not effective in decreasing or delaying HF burn development. The results indicated that calcium gluconate ointment was the most effective topical treatment for HF burns.

AN: 86061946

MEDLINE EXPRESS (R) 1984-1990 78 of 324

TI: [Treatment of children with persistent cough in pharyngitis]

TO: Lechenie detei, stradaiushchikh dlitel'nym kashlem pri faringite.

AU: Grigor'eva-IF

SO: Vestn-Otorinolaringol. 1985 Jul-Aug(4): 13-6

This title is owned by this library